An error occurred while communicating with the remote host. Error code: 0x80070001

We recently moved our websites to new servers running Windows 2008 R2 / IIS7.5 and started getting the following error:

Exception information: 
    Exception type: HttpException 
    Exception message: An error occurred while communicating with the remote host. The error code is 0x80070001.
   at System.Web.Hosting.IIS7WorkerRequest.RaiseCommunicationError(Int32 result, Boolean throwOnDisconnect)
   at System.Web.Hosting.IIS7WorkerRequest.ReadEntityCoreSync(Byte[] buffer, Int32 offset, Int32 size)
   at System.Web.HttpRequest.GetEntireRawContent()
   at System.Web.HttpRequest.FillInFormCollection()
   at System.Web.HttpRequest.get_Form()
   at System.Web.HttpRequest.get_HasForm()
   at System.Web.UI.Page.GetCollectionBasedOnMethod(Boolean dontReturnNull)
   at System.Web.UI.Page.DeterminePostBackMode()
   at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)

Specified method is not supported.
   at System.Web.HttpResponseStream.get_Position()
   at System.Drawing.UnsafeNativeMethods.ComStreamFromDataStream.Seek(Int64 offset, Int32 origin)

      

        
        
        
      

    

The error seems to happen in a rather random fashion on several different pages and we cannot reproduce it ourselves.

I am reviewing this site and others for similar examples but haven't found a solution yet. The general answer seems to be that it has something to do with TCP and / or VMware offloading. We're not using virtualization, so is this the only solution to disable TCP offloading? What will be the impact of disabling it?