Decimal point from the control panel Setting options

I am creating an application with VB.NET

As stated on MSDN, I changed the Culture to en-US. It works to override the decimal point to point if the user sets the regional format to any comma-separated language.

Public Sub New()

    Thread.CurrentThread.CurrentCulture = New CultureInfo("en-US")
    Thread.CurrentThread.CurrentUICulture = New CultureInfo("en-US")

    InitializeComponent()

End Sub

      

        
        
        
      

    

Now the problem is , how can I override the decimal separator if the user has changed the system decimal separator from Control Panel> Region and Language> Advanced Settings (under Format tab)?

CultureInfo cannot override these custom settings. I need to override the entire decimal point separator without using the string replace function.