Huge difference between api response and application web transaction times?

My frontend app connects to api server to get its data, the transaction times of the third party app web interface is as below picture.

Frontend app web transactions response time

Although the api response time is almost ~ 100ms, the frontend application web transaction response time is almost ~ 600ms.

Api response time

And what could be causing the 400ms difference?

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networking connection newrelic


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