What is the correct way to create an adventure game with PyGame?

I started development on a small 2d adventure side view with a few people. The game will consist of common elements: room, main character, inventory, npcs, items and puzzles. We chose PyGame because we are all already familiar with python. My question is pretty theoretical, but how would we design this well? Will every object on the screen talk to some kind of basic outline that hits everything on the screen? (Hope this isn't too much of a discussion-y) Thanks